five.eighteen Intense Hypotension Promethazine HCl and codeine phosphate oral solution may perhaps trigger extreme hypotension such as orthostatic hypotension and syncope in ambulatory patients. There is enhanced risk in people whose ability to keep up blood pressure has now been compromised by a minimized blood quantity or concurrent administration of sure CNS depressant prescription drugs (e.
Respiratory problems (respiratory despair) that can cause Dying and opioid withdrawal can occur if You begin taking or end getting other medicines although getting Promethazine Hydrochloride and Codeine Phosphate Oral Option, which includes:
Chance Summary Promethazine HCl and codeine phosphate oral Remedy just isn't advised to be used in pregnant Women of all ages, including during or immediately prior to labor.
The effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are elaborate, demanding cautious thing to consider of the consequences on the parent drug, codeine, and the Energetic metabolite, morphine.
Even so, this influence is not really consistent and could be offset by a heightened fee of cervical dilation, which has a tendency to shorten labor. Watch neonates subjected to opioids throughout labor for signs of excess sedation and respiratory depression.
Outcomes to the Cardiovascular Process Codeine generates peripheral vasodilation which may lead to orthostatic hypotension or syncope. Manifestations of histamine release and/or peripheral vasodilation may perhaps include things like pruritus, flushing, purple eyes and sweating and/or orthostatic hypotension.
DailyMed will produce this notification in your desktop, Website browser, or e-mail depending on the RSS Reader you select to implement. To see up-to-date drug label one-way links, paste the RSS feed address (URL) shown under into a RSS reader, or make use of a browser which supports RSS feeds, for instance Safari for Mac OS X.
Promethazine Signs and symptoms of overdosage with promethazine vary from mild melancholy of the central anxious system and cardiovascular process to profound hypotension, respiratory depression, unconsciousness and sudden death.
Use caution When thinking about the use of promethazine HCl and codeine phosphate oral Resolution in individuals 65 a long time of age or older.
In animal replica research, codeine administered via the oral route to pregnant rats in the course of the duration of organogenesis elevated resorptions and decreased fetal weights at a dose about twenty five times the maximum advisable human dose (MRHD) during the presence of maternal toxicity (see Facts).
We foresee reposting the pictures once we've been capable determine and filter out visuals that do not match the data presented in the drug labels. NDC Codes
Human Facts Revealed info from case-control and observational studies on codeine use all through pregnancy are inconsistent inside their findings. Some get more info studies of codeine exposure showed an elevated chance of All round congenital malformations while some did not. A heightened risk of precise malformations with codeine exposure for instance respiratory malformations, spina bifida and congenital heart defects have been reported in a few experiments.
Focus–Adverse Response Interactions There's a romance in between rising codeine plasma focus and expanding frequency of dose-associated opioid adverse reactions for example nausea, vomiting, CNS outcomes, and respiratory despair.
DailyMed will deliver notification of updates and additions to Drug Label details now shown on this site via its RSS feed.